METHOD FOR THE CHEMO-SELECTIVE ENZYMATIC HYDROLYSIS IF A DIESTER COMPOUND FOR PREPARING A MONOESTER MONOACID COMPOUND

摘要

The invention relates to a synthesis method. The method relates to the synthesis of the compound of the formula (I) according to the following diagram A, in which R1, R2, R3 are identical or different and represent an alkyl group, characterised by an enzymatic hydrolysis reaction that comprises contacting the compound of the formula (II) with an enzyme that carries out an chemo-selective hydrolysis of only one of the two ester functions of the compound of the formula (II) in order to obtain the compound of the formula (I). The invention can be used for the industrial preparation of an intermediate product of the formula (I) that can be used for preparing a pharmaceutically active ingredient, i.e. the Repaglinide.