| 摘要 |
<p>The present invention relates to protracted human insulinderivatives in which the A21 and the B3 amino acid residues are,independently, any amino acid residue which can be coded by thecode except Lys, Arg and Cys; PheB1 may be deleted; the B30 aminoacid residue is a) a non-codable, lipophilic amino acid havingfrom 10 to 24 carbon atoms, in which case an acyl group of acarboxylic acid with up to 5 carbon atoms is bound to the -aminogroup of LysB29; or b) the B30 amino acid residue is deleted or isany amino acid residue which can be coded for by the genetic codeexcept Lys, Arg and Cys, in any of which cases the -amino groupof LysB29 has a lipophilic substituent; and when B30 is Thr or Alaand A21 and B3 are both Asn, and Pheb1 is present, then theinsulin derivative is always present as a Zn2+ complex.</p> |
