METHOD OF TESTING INTEGRITY OF MICROPOROUS MEMBRANE

摘要

[PROBLEMS] To provide: a membrane integrity test method using a colloidal solution containing a metal particle or a metal compound particle, which ca n test on the integrity of a virus removal membrane comprising a hydrophiliz ed synthetic polymer accurately after the filtration of a protein solution t hrough the membrane; and a method for producing the colloidal solution. [MEA NS FOR SOLVING PROBLEMS] An integrity test method for a microporous membrane , which comprises the step of filtering a colloidal solution comprising a so lvent and a metal particle dispersed in the solvent through a microporous me mbrane, wherein the solvent comprises the components (A) and (B), the compon ents (A) and (C), or the components (A), (B) and (C) mentioned below: (A) an anionic polymer having a sulfonate group, (B) at least one non-ionic surfac tant selected from the group consisting of a non-ionic surfactant having a p olycyclic structure in a hydrophobic moiety and an non-ionic surfactant of a polyoxyethylene sorbitan fatty acid ester; and (C) a water-soluble polymer having a pyrrolidone group.