发明名称 MONOCYCLIC ANILIDE SPIROLACTAM CGRP RECEPTOR ANTAGONISTS
摘要 The present invention is directed to compounds of Formula I: I (where var iables A1, A2, B, J, K, m, n, R4, R5a, R5b and R5c are as defined herein) us eful as antagonists of CGRP receptors and useful in the treatment or prevent ion of diseases in which the CGRP is involved, such as headache, migraine an d cluster headache. The invention is also directed to pharmaceutical composi tions comprising these compounds and the use of these compounds and composit ions in the prevention or treatment of such diseases in which CGRP is involv ed.
申请公布号 CA2680307(A1) 申请公布日期 2008.09.18
申请号 CA20082680307 申请日期 2008.03.07
申请人 MERCK & CO., INC. 发明人 STUMP, CRAIG A.;SELNICK, HAROLD G.;BELL, IAN M.
分类号 A61K31/44;A61K31/40 主分类号 A61K31/44
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