SOLID CHIRAL ZIRCONIUM CATALYST AND SYNTHETIC METHOD OF ALDOL REACTION PRODUCT OR CYCLIZED COMPOUND USING THE SAME

摘要

PROBLEM TO BE SOLVED: To provide a solid chiral zirconium catalyst which is capable of effecting long-term preservation and which is suitable for catalystic asymmetry aldol reaction and catalytic asymmetry hetero Diels-Alder reaction and to provide a synthetic method of an aldol reaction product or cyclized compound using the same.

SOLUTION: The synthetic method uses a powder zirconium catalyst obtained by reacting a binaphthol or its enantiomer with a zirconium compound in an organic solvent, adding a nonpolar solvent to the reaction mixture and isolating the resulting solid precipitation.

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