Single phase pharmaceutical compositions for topical application, in addition to kits and methods of use and administration are provided. The compositions comprise a biologically active agent; a delivery vehicle comprising at least a non- polymeric crystallization inhibitor and a film-former; and a volatile solvent; wherein the biologically active agent is present in the composition in a subsaturated state, the biologically active agent is present in the delivery vehicle in a supersaturated state, and the crystallization inhibitor is capable of delaying crystallization of the biologically active agent in the delivery vehicle. Biologically active agents include terbinafme and acyclovir. Treatments for onychomycosis and Varicella zoster infection, HSV-I infection or HSV-2 infection are provided.
申请公布号
WO2007147052(A3)
申请公布日期
2008.09.18
申请号
WO2007US71212
申请日期
2007.06.14
申请人
DR. REDDY'S LABORATORIES LIMITED;DR. REDDY'S LABORATORIES, INC.;LINDAHL, AAKE;SVENSSON, BIRGITTA;HOLMBERG, ANNA;ENGBLOM, JOHAN
发明人
LINDAHL, AAKE;SVENSSON, BIRGITTA;HOLMBERG, ANNA;ENGBLOM, JOHAN