Method for the Preparation of Enantiomerically Enriched Secondary Alcohols by the Addition of Organoaluminium Reagents to Carbonyl Compounds

摘要

A process for converting a carbonyl group within a substrate to a chiral alcohol moiety comprising reacting the carbonyl containing substrate with an organoaluminium reagent in the presence of a Group 5-12 transition metal based catalyst which is complexed with a chiral ligand; novel chiral ligands and organoluminium reagents, a chiral ligand or organoaluminium reagent for use in the process.