发明名称 |
K-RAS AND B-RAF MUTATIONS AND ANTI-EGFR ANTIBODY THERAPY |
摘要 |
The present application relates to K-ras mutations, to polynucleotides encoding mutant K-ras polypeptides, and to methods of identifying K-ras mutations. The present application also relates to B-raf mutations, to polynucleotides encoding mutant B-raf polypeptides, to vectors containing those polynucleotides, and to methods of identifying B-raf mutations. The present application also relates to methods of diagnosing cancer; and methods and kits for predicting the usefulness of anti-EGFr specific binding agents in the treatment of tumors. |
申请公布号 |
WO2008112274(A2) |
申请公布日期 |
2008.09.18 |
申请号 |
WO2008US03327 |
申请日期 |
2008.03.11 |
申请人 |
AMGEN INC.;SIENA, SALVATORE;BARDELLI, ALBERTO |
发明人 |
SIENA, SALVATORE;BARDELLI, ALBERTO |
分类号 |
C12Q1/68 |
主分类号 |
C12Q1/68 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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