PYRAZOLO (3, 4-B) PYRIDINE DERIVATIVES AS PHOSPHODIESTERASE INHIBITORS

摘要

The present invention relates to phosphodiesterase (PDE) type 4, phosphod iesterase (PDE) type 7 and dual PDE type 4 /PDE type 7 inhibitors. Compounds disclosed herein having the structure of Formura 1: can be useful in the tr eatment, prevention, inhibition or suppression of CNS diseases, for example, multiple sclerosis; various pathological conditions such as diseases affect ing the immune system, including AIDS, rejection of transplant, auto-immune disorders such as T-cell related diseases, for example, rheumatoid arthritis ; inflammatory diseases such as respiratory inflammation diseases including chronic obstructive pulmonary disease (COPD), asthma, bronchitis, allergic r hinitis, adult respiratory distress syndrome (ARDS) and other inflammatory d iseases including but not limited to psoriasis, shock, atopic dermatitis, eo sinophilic granuloma, allergic conjunctivitis, osteoarthritis; gastrointesti nal inflammation diseases such as Crohn's disease, colitis, pancreatitis as well as different types of cancers including leukaemia; especially in humans . Processes for the preparation of disclosed compounds, pharmaceutical compo sitions containing the disclosed compounds and their use as PDE type 4, PDE type 7 and dual PDE type 4 /PDE type 7 inhibitors are provided.