发明名称 Hydroxyphenylalkadiones and Their Use for Masking Bitter Taste and/or for Intensifying Sweet Taste
摘要 The use of a hydroxyphenylalkadione derivative of the formula (I) wherein, for X, a and Y: X is a -CH<SUB>2</SUB>-, -NH- or -O- group, Y is a -CH<SUB>2</SUB>- group and a is a single bond or X and Y are in each case a -CH- group and a is a double bond in the Z or E configuration, wherein, for R<SUP>1</SUP>, R<SUP>2 </SUP>and R<SUP>3 </SUP> R<SUP>1 </SUP>denotes hydrogen, an aliphatic radical having 1 to 4 C atoms or a -O-R<SUP>5</SUP>, -S-R<SUP>5 </SUP>or -NR<SUP>5</SUP>R<SUP>6 </SUP>group and R<SUP>2 </SUP>and R<SUP>3 </SUP>independently of one another denote hydrogen or an alkyl having 1, 2, 3, 4 or 5 C atoms which is optionally substituted by one or more oxo groups or R<SUP>7</SUP>-O- groups or R<SUP>1 </SUP>and R<SUP>2 </SUP>together form an aliphatic ring which contains a total of 4 to 10 carbon atoms and 0 or 1 oxygen atom, wherein the ring constituent represented by R<SUP>1 </SUP>and R<SUP>2 </SUP>is optionally substituted by one or more oxo groups and/or R<SUP>7</SUP>-O- groups and/or aliphatic radicals having 1 to 4 C atoms and R<SUP>3 </SUP>denotes hydrogen or an alkyl having 1, 2, 3, 4 or 5 C atoms which is optionally substituted by one or more oxo groups or R<SUP>7</SUP>-O- groups or R<SUP>2 </SUP>and R<SUP>3 </SUP>together form an aliphatic ring which contains a total of 4 to 10 carbon atoms and 0 or 1 oxygen atom, wherein the ring constituent represented by R<SUP>2 </SUP>and R<SUP>3 </SUP>is optionally substituted by one or more oxo groups and/or R<SUP>7</SUP>-O- groups and/or aliphatic radicals having 1 to 4 C atoms and R<SUP>1 </SUP>denotes hydrogen, an aliphatic radical having 1 to 4 C atoms or a -O-R<SUP>5</SUP>, -S-R<SUP>5 </SUP>or -NR<SUP>5</SUP>R<SUP>6 </SUP>group, wherein, for R<SUP>4 </SUP>and R: R<SUP>4 </SUP>and R independently of one another denote hydrogen, methyl or ethyl and wherein, for R<SUP>5</SUP>, R<SUP>6 </SUP>and R<SUP>7</SUP>: R<SUP>5</SUP>, R<SUP>6 </SUP>and R<SUP>7 </SUP>independently of one another denote hydrogen or an aliphatic radical having 1 to 4 C atoms, a salt of such a hydroxyphenylalkadione of the formula (I), a mixture comprising or consisting of two or more different hydroxyphenylalkadiones of the formula (I), wherein X, a, Y, R, R<SUP>1</SUP>, R<SUP>2</SUP>, R<SUP>3</SUP>, R<SUP>4</SUP>, R<SUP>5</SUP>, R<SUP>6 </SUP>and R<SUP>7 </SUP>in each case have the meaning given above, a mixture comprising or consisting of salts of two or more different hydroxyphenylalkadiones of the formula (I), wherein X, a, Y, R, R<SUP>1</SUP>, R<SUP>2</SUP>, R<SUP>3</SUP>, R<SUP>4</SUP>, R<SUP>5</SUP>, R<SUP>6 </SUP>and R<SUP>7 </SUP>in each case have the meaning given above, or a mixture comprising or consisting of a hydroxyphenylalkadione of the formula (I) or two or more different hydroxyphenylalkadiones of the formula (I), wherein X, a, Y, R, R<SUP>1</SUP>, R<SUP>2</SUP>, R<SUP>3</SUP>, R<SUP>4</SUP>, R<SUP>5</SUP>, R<SUP>6 </SUP>and R<SUP>7 </SUP>in each case have the meaning given above, and a salt of a hydroxyphenylalkadione of the formula (I) or two or more salts of different hydroxyphenylalkadiones of the formula (I), wherein X, a, Y, R, R<SUP>1</SUP>, R<SUP>2</SUP>, R<SUP>3</SUP>, R<SUP>4</SUP>, R<SUP>5</SUP>, R<SUP>6 </SUP>and R<SUP>7 </SUP>in each case have the meaning given above, for modifying, masking or reducing the unpleasant flavour impression of an unpleasantly tasting substance and/or for intensifying the sweet taste of a sweet-tasting substance and/or the sweet odour impression of an aroma substance which causes a sweet odour impression, as well as formulations and processes including a hydroxyphenylalkadione of the formula (I), are described.
申请公布号 US2008227866(A1) 申请公布日期 2008.09.18
申请号 US20060994452 申请日期 2006.06.27
申请人 SYMRISE GMBH & CO. KG 发明人 LEY JAKOB;BERTRAM HEINZ-JURGEN;KRAMMER GERHARD E.;KINDEL GUNTER
分类号 A61K31/12;A23L1/22;C07C49/255 主分类号 A61K31/12
代理机构 代理人
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