发明名称 Process for preparing 2,4-dioxo-3-azabicyclo[3.1.0]Hexanes
摘要 A process for preparing a compound of formula (I):cycloalkyl or benzyl, and wherein the phenyl moiety of said benzyl group is optionally substituted with one or two substituents each independently selected from halo, nitro, C1-C6 alkyl, C1-C6 alkoxy, amino and trifluoromethyl, which comprises treating a solution of a compound of formula (II): <IMAGE> (II) wherein R is as defined for formula (I), and a halonitromethane in a first organic solvent, with a quaternary ammonium fluoride of formula (III): R1R2R3F4N+E,crc ++EE F+E,crc -+EE (III) wherein R1,R2,R3 and R4 are each independently selected from C1-C8 alkyl and benzyl, optionally in solution in a second organic solvent.
申请公布号 US5847158(A) 申请公布日期 1998.12.08
申请号 US19970878909 申请日期 1997.06.19
申请人 PFIZER INC. 发明人 LAWSON, NICHOLAS JOHN
分类号 C07D209/52;(IPC1-7):C07D209/38;C07D225/00 主分类号 C07D209/52
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