INCREASED EFFECTIVENESS OF MDA-7 WITH MDR-1 OVER-EXPRESSION

摘要

The present invention relates to the use of melanoma differentiation associated gene-7, its encoded protein, and related molecules (Collectively, "Mda-7 Molecules") for improving the response of a subject to chemotherapy and the particular benefit of Mda-7 treatment in a subject resistant to chemotherapy. It is based, at least in part, on the discovery that mda-7 expression increases the response of hitherto resistant cells to chemotherapeutic agent, as well as on the discovery that mda-7 expression is itself enhanced in the context of over- expression of the multidrug resistance gene (mdr-l).