| 摘要 |
Methods, systems, and related computer program products are provided for the reliable measurement of absolute chromophore concentrations in biological tissue, such as those indicative of blood oxygenation levels in the brain, based on infrared optical scanning. A plurality of probe patches is positioned at a respective plurality of locations around the patient's head, each probe patch being positioned against the skin of the head, wherein at least one of the probe patches is positioned where the skin includes active hair follicles. Each probe patch comprises a first infrared source-detector pair having a relatively short source-detector spacing and a second infrared source-detector pair having a relatively long source-detector spacing. Phase-only measurements are acquired for each of a plurality of infrared radiation wavelengths and modulation frequencies for each source-detector pair. Absolute regional chromophore concentrations in the brain are computed based on the phase-only measurements.
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