| 摘要 |
<p>The use of compounds is described which are capable of functionally block ing at least one of the genes chosen from the group composed of EphA1, EphA2 , EphA8, EphB2, CSF1R, VEGFR2, RAMP2, RAMP3, CLRN1, MAPK4, PIK3C2A, PIK3CG, GSK3alpha, GSK3beta, IRAK3, DAPK1, JAK1, PIM1, TRB3, BTG1, LATS1, LIMK2, MYL K, PAK1, PAK2, CDC2, BTK, PNRC2, NCOA4, NR2C1, TPR, RBBP8, TRPC7, FXYD1, ERN 1, PRSS16, RPS3, CCL23 and SERPINE1, for the manufacture of a medicament des tined to diminish the resistance to chemotherapeutic drugs in the therapeuti c treatment of epithelial tumour pathologies. Also described is a method for the determination of the drug resistance in tumour cells, as well as a meth od forthe identification of tumour stem cells.</p> |
