| 摘要 |
The present invention relates to the use of pyrrolidine and piperidine derivatives of the general formulae <CHEM> wherein R<1> and R<2> are, independently from each other, hydrogen, lower alkoxy, hydroxy, halogen, -CONH2 or -C(O)O-lower alkyl; or taken together are -O-CH2-O-; R<3> and R<4> are, independently from each other, hydrogen, lower alkoxy, benzyloxy, halogen, hydroxy, -CONH2 or -SCH3; or taken together are -O-CH2-O-; R<5> is hydrogen or lower alkyl; X and Y are, independently from each other -CH(OH)-, -(CH2)n-, -C(O)- or -CH(lower alkoxy)-; and m, n and p are 1 or 2; and to their pharmaceutically acceptable addition salts for the treatment of diseases caused by overactivation of NMDA receptor subtypes. |
