PHARMACEUTICAL COMPOSITIONS AND METHODS FOR IMPROVED BACTERIAL ERADICATION

摘要

Disclosed are once-a-day penicillin-type antibiotic products, comprising at least one modified release dosage form comprising penicillin-type antibiotics and pharmaceutically acceptable carriers, that are administered once-a-day in a dosage and for a number of days that provide a Total T>MIC that is sufficient to achieve at least the minimum amount of bacterial eradication for treatment of a bacterial infection. In one embodiment the products provide a T>MIC₉₀ in the serum for at least 5 hours (preferably for at least five consecutive hours), within a 24-hour dosing interval, for a given bacterial pathogen's MIC₉₀, while providing a total dosage of the penicillin-type antibiotic for a 24-hour dosing interval.