| 发明名称 |
Cis-imidazolines |
| 摘要 |
The present invention provides compounds according to formula I having the designations provided herein, and pharmaceutically acceptable salts and esters thereof. These compounds inhibit the interaction of MDM2 protein with a p53-like peptide and have antiproliferative activity.
|
| 申请公布号 |
US7425638(B2) |
申请公布日期 |
2008.09.16 |
| 申请号 |
US20040867154 |
申请日期 |
2004.06.14 |
| 申请人 |
HOFFMANN-LA ROCHE INC. |
发明人 |
HALEY GREGORY JAY;KONG NORMAN;LIU EMILY AIJUN;SIMONSEN KLAUS B.;VU BINH THANH;WEBBER STEPHEN EVAN |
| 分类号 |
C07D233/22;A61K31/4164;A61K31/454;A61K31/496;C07D401/06;C07D401/12;C07D403/12;C07D405/12;C07D409/12;C07D417/12 |
主分类号 |
C07D233/22 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
|
| 地址 |
|
