SPECIFIC BINDING MEMBERS FOR HUMAN CARCINOEMBRYONIC ANTIGEN,MATERIALS AND METHODS

摘要

Sequence and binding information is provided for particularly advantageous specific binding members which bind human carcinoembryonic antigen (CEA) with a dissociation constant which is less th an 1,0 .times. 10 -8M, are substantially non-cross-reactive with human liver cells, bind to the A3-B3 extracellular domain of human carcinoembryonic antigen and/or bind to cell-associated human carcinoembryonic antigen preferentially over soluble human carcinoembryonic antigen. These are useful particularly in determination of CEA expression by cells such as tumour cells.