发明名称 |
Antihelminthic drugs as a treatment for hyperproliferative diseases |
摘要 |
The present invention is directed to the use of benzimidazole derivatives for the treatment of tumors and in combination with tumor suppressor gene therapy. In a particular embodiment, treatment of p53-positive tumors with benzimidazole derivatives induces p53 expression and increases its half-life, resulting in apoptotic death of the tumor cells. Similarly, in conjunction with p53 gene therapy, benzimidazole derivatives induce p53 expression and accumulation in tumor cells regardless of their p53 status. The combination treatment subsequently elicits apoptosis of the tumor cells.
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申请公布号 |
US7423015(B1) |
申请公布日期 |
2008.09.09 |
申请号 |
US20020043877 |
申请日期 |
2002.01.09 |
申请人 |
BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM;INTROGEN THERAPEUTICS, INC. |
发明人 |
MUKHOPADHYAY TAPAS;CHADA SUNIL;MHASHILKAR ABNER;ROTH JACK A. |
分类号 |
A61K31/4184;A61K31/4439;A61P1/00;A61P19/02;A61P35/00 |
主分类号 |
A61K31/4184 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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