发明名称 |
MULTIPARTICULATE PHARMACEUTICAL FORM WITH PROGRAMMED AND TIMED RELEASE AND PREPARATION METHOD. |
摘要 |
<p>The invention concerns a mutliparticulate pharmaceutical form with delayed and timed release for starting to make the active principle available 4 to 8 hours after said pharmaceutical form has been ingested, then for gradually releasing the totality of the active principle within the following 8 to 20 hours. The invention is characterised in that it is free of organic acid and it is in the form of medicated spheroids consisting of a neutral spherical carrier comprising a first coating based on a mixture of at least a water soluble polymer and at least a water insoluble polymer wherein are uniformly distributed particles constituting an active principle, the whole comprising a second coating based on at least two independent pH polymers, having degrees of permeability with respect to different gastric and intestinal environments, optionally at least a dependent pH polymer, at least a plasticising agent and at least an inert filler distributed in said coating.</p> |
申请公布号 |
MXPA00011364(A) |
申请公布日期 |
2008.09.09 |
申请号 |
MX2000PA11364 |
申请日期 |
1999.05.20 |
申请人 |
ETHYPHARM |
发明人 |
EDOUARD GENDROT;COUSIN, GERARD;RAGOT, FRANCOISE;CLEE-BOUVET, MARIE-CHRISTINE |
分类号 |
A61K9/54;A61K9/16;A61K9/50;A61K9/52;A61K9/58;A61K31/275;A61K31/554;A61K47/02;A61K47/14;A61K47/32;A61K47/38;A61P9/00;A61P29/00;A61P37/08;A61P43/00 |
主分类号 |
A61K9/54 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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