Tricyclic Lactam Derivatives as 11-Beta Hydroxysteroid Dehydrogenase Inhibitors

摘要

the N-oxide forms, the pharmaceutically acceptable addition salts and the stereochemically isomeric forms thereof, wherein X represents C or N; Y represents C or N; L represents a methyl or a direct bond; Z¹ represents a direct bond, C_1-2alkyl- or a divalent radical of formula -CH₂-CH- (a) or -CH- (b); Z² represents a direct bond, C_1-2alkyl- or a divalent radical of formula -CH₂-CH- (a) or -CH- (b); R¹ represents hydrogen, halo, cyano, amino, phenyl, hydroxy, C_1-4alkyloxycarbonyl, hydroxycarbonyl, NR³R⁴ or C_1-4alkyl optionally substituted with one or more substituents selected from hydroxycarbonyl, phenyl, C_1-4alkyloxy or NR⁵R⁶ or R¹ represents C_1-4alkyloxy- optionally substituted with one or more substituents selected from hydroxycarbonyl, phenyl, C_1-4alkyloxy or NR⁷R⁸; R² represents hydrogen, halo, C_1-4alkyl or C_1-4alkyloxy-; R³ and R⁴ each independently represent hydrogen, C_1-4alkyl or C_1-4alkylcarbonyl-; R⁵ and R⁶ each independently represent hydrogen, C_1-4alkyl or C_1-4alkylcarbonyl-; R⁷ and R⁸ each independently represent hydrogen, C_1-4alkyl or C_1-4alkylcarbonyl-; A represents phenyl or a monocyclic heterocycle selected from the group consisting of thiophenyl, furanyl, oxazolyl, thiazolyl, imidazolyl, isoxazolyl, isothiazolyl, pyrridinyl, pyridazinyl, pyrimidinyl and piperazinyl.