REXINOID COMPOUND HAVING ALKOXY GROUP

摘要

Disclosed is a compound represented by the general formula shown below, which can bind to a retinoid X receptor (RXR) (which is one of nuclear receptors) to exhibit an agonistic or antagonistic activity on the receptor. wherein R¹ is selected from the group consisting of an alkyl group, an alkenyl group, an alkynyl group and an aryl group; R² is selected from the group consisting of an alkoxy group, an alkyl group, an alkenyl group, an alkynyl group and an aryl group; W represents NR³ or CR³; R³ is selected from a hydrogen, an alkyl group, an alkenyl group, an alkynyl group and an aryl group; X¹ and Y¹ are independently selected from CH and N; X² and Y² are independently selected from CH, CR⁴ and N; R⁴ is selected from an alkyl group, an alkenyl group, an alkynyl group, an alkoxy group, a halogen, a nitro group and an amino group; and Z is selected from a carboxylic acid, a carboxylate ester and a hydroxamic acid which is bound directly or via an alkyl group, an alkenyl group or an alkynyl group.