Disclosed is a transdermal pharmaceutical composition characterized by blending eptazocine hydrobromide with a fatty acid ester, a glycerin fatty acid ester and a glycol or a pyrrolidone. Also disclosed is a method for enhancing the transdermal absorption of eptazocine hydrobromide. The transdermal pharmaceutical composition is significantly improved in absorption of eptazocine hydrobromide through the skin, and enables the penetration of a desired amount of eptazocine hydrobromide through the skin without the need of employing injection. Therefore, the transdermal pharmaceutical composition is highly useful as a pharmaceutical agent having an excellent analgesic effect.
