发明名称 |
ACID ADDITION SALTS, HYDRATES AND POLYMORPHS OF 5-(2,4-DIHYDROXY-5-ISOPROPYL-PHENYL)-4-(4-MORPHOLIN-4-YLMETHYL-PHENYL)-ISOXAZOLE-3-CARBOXYLIC ACID ETHYLAMIDE AND FORMULATIONS COMPRISING THESE FORMS |
摘要 |
<p>The present invention relates to new salt forms of 5-(2,4-dihydroxy-5-isopropyl-phenyl)-4-(4- morpholin-4-ylmethyl-phenyl)-isoxazole-3-carboxylic acid ethylamide, in particular the mesylate, hydrochloride, tartrate, phosphate and hemi fumarate salt thereof; to crystalline forms of such salts; to polymorphs of 5-(2,4-dihydroxy-5-isopropyl-phenyl)-4-(4-morpholin-4- ylmethyl-phenyl)-isoxazole-3-carboxylic acid ethylamide; to hydrates and polymorphs of the new salt forms mentioned above; to the use of the new salt forms mentioned above for the manufacture of a medicament for the treatment of a disorder mediated by Hsp90; to a method for treating a disorder mediated by Hsp90 using the new salt forms; to formulations comprising such salt forms, in particular aqueous solutions suitable for intravenous administration; and to amber glass containers being filled with such formulations.</p> |
申请公布号 |
WO2008104595(A1) |
申请公布日期 |
2008.09.04 |
申请号 |
WO2008EP52443 |
申请日期 |
2008.02.28 |
申请人 |
NOVARTIS AG;VERNALIS (R & D) LTD.;DRYSDALE, MARTIN JAMES;DYMOCK, BRIAN WILLIAM;KRELL, CHRISTOPH;MUTZ, MICHAEL;PETERSEN, HOLGER;ZHENG, WEIJIA |
发明人 |
DRYSDALE, MARTIN JAMES;DYMOCK, BRIAN WILLIAM;KRELL, CHRISTOPH;MUTZ, MICHAEL;PETERSEN, HOLGER;ZHENG, WEIJIA |
分类号 |
A61K31/5377;A61P35/00;C07D295/00 |
主分类号 |
A61K31/5377 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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