| 摘要 |
<p>Compounds represented by the general formula (1) which have potent inhibitory effect on Rho-kinase, salts of the same, or derivatives of both serving as prodrugs: (1) wherein A is a nitrogenous saturated ring; m is an integer of 0 to 2; n is an integer of 1 to 4; G<SUP>1</SUP> is hydrogen, chloro, hydroxy, alkoxy, or amino; G<SUP>2</SUP> is halogeno, hydroxy, cyano, carboxy, alkyl, alkenyl, or the like; G<SUP>3</SUP> is hydrogen, halogeno, hydroxy, cyano, carboxy, alkyl, alkenyl, or the like; G<SUP>4</SUP> is hydroxy or -N(R<SUP>1</SUP>)(R<SUP>2</SUP>) (wherein R<SUP>1</SUP> and R<SUP>2</SUP> are each hydrogen, alkyl, aralkyl, alkenyl, alkynyl, or a saturated heterocyclic group); and G<SUP>5</SUP> is a substituent on a carbon atom constituting the ring A and is hydrogen, fluoro or alkyl.</p> |
