发明名称 |
NOVEL PYRROLE DERIVATIVE HAVING UREIDE GROUP AND AMINOCARBONYL GROUP AS SUBSTITUENTS |
摘要 |
<p>The object is to study on the synthesis of a novel pyrrole derivative having an ureide group and an aminocarbonyl group as substituents or a salt thereof, to find a pharmacological effect of the derivative or the salt thereof, and to find a substance which exhibits a prophylactic and/or therapeutic effect on a retinal disease or the like through oral administration. A compound represented by the general formula (1) or a salt thereof has an inhibitory effect on the production of interleukin-6 and/or an inhibitory effect on choroidal angiogenesis, and is therefore useful as a prophylactic and/or therapeutic agent for a disease associated with interleukin-6, an ophthalmic inflammatory disease and/or a retinal disease. In the formula, the ring A represents a benzene ring or the like; R<SUP>1</SUP> represents a halogen atom, a hydrogen atom, a lower alkyl group or the like; R<SUP>2</SUP> represents a halogen atom, a lower alkyl group which may have a substituent, a lower alkenyl group, a lower alkynyl group which may have a substituent, a lower cycloalkyl group, an aryl group, a hydroxy group, a lower alkoxy group which may have a substituent or the like; and n represents a number of 0, 1, 2, 3 or the like.</p> |
申请公布号 |
WO2008105408(A1) |
申请公布日期 |
2008.09.04 |
申请号 |
WO2008JP53297 |
申请日期 |
2008.02.26 |
申请人 |
SANTEN PHARMACEUTICAL CO., LTD.;KAWASHIMA, KENJI;ENOMOTO, HIROSHI;ISHIZAKA, NORIKO;YAMAMOTO, MINORU;KUDOU, KAZUHIRO;MURAI, MASAAKI;INABA, TAKAAKI;OKAMOTO, KAZUYOSHI |
发明人 |
KAWASHIMA, KENJI;ENOMOTO, HIROSHI;ISHIZAKA, NORIKO;YAMAMOTO, MINORU;KUDOU, KAZUHIRO;MURAI, MASAAKI;INABA, TAKAAKI;OKAMOTO, KAZUYOSHI |
分类号 |
C07D207/416;A61K31/40;A61K31/422;A61K31/427;A61K31/4439;A61K31/454;A61K31/496;A61K31/5377;A61P3/10;A61P9/10;A61P27/02;A61P35/00;A61P43/00;C07D401/04;C07D401/12;C07D403/12;C07D413/12;C07D417/12 |
主分类号 |
C07D207/416 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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