| 摘要 |
The present invention relates to radiolabelled substitute benzene compoun ds for diagnostic imaging. The present invention provides methods for prepar ation of such compounds, in particular, preparation of novel compounds which serve as precursors for 18F-labeling, and the use of thus 18F-labe!ed compo unds for diagnostic imaging. Formula (A), wherein one of -Y1, -Y2, -Y3 Y4 an d -Y5 is -A-B-D-P, wherein -A-B-D- is a bond or spacer, P is peptide, peptid omimetic, oligonucleotide or small molecule. K is LG-O or W, wherein: LG- is selected from the group comprising Formula (B), wherein T is H or Cl, Q is CH or N, K is absent or is C=O. W is radioactive or non-radioactive isotope of fluorine, more preferably 18F.
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