| 摘要 |
It is disclosed herein that Brachyury is expressed in human tumors, speci fically in tumors of the small intestine, stomach, kidney, bladder, uterus, ovary, and testes, as well as in lung, colon and prostate carcinomas. Immuno genic Brachyury polypeptides are disclosed herein. These polypeptides can be used in diagnostic assays for Brachyury expression, as well as for inducing an immune response to Brachyury. Polynucleotides encoding the immunogenic B rachyury polypeptides, vectors including these polypeptides, host cells tran sformed with these vectors, and methods of using these polypeptides, polynuc leotides, vectors, and host cells are provided. Methods of diagnosing a Brac hyury-expressing cancer are also provided. Exemplary cancers include small l ung, colon, intestine, stomach, kidney, bladder, uterus, ovary, and testes a nd prostate cancers. Methods of treating cancer are also disclosed.
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