发明名称 |
Butyrylcholinesterase Variants that Alter the Activity of Chemotherapeutic Agents |
摘要 |
The invention provides a butyrylchinesterase variant, a method of converting a camptothecin derivative to a topoisomerase inhibitor by contacting the camptothecin derivative with a butyrylcholinesterase variant and a method of treating cancer by administering to an individual an effective amount a butyrylcholinesterase variant exhibiting increased capability to convert a camptothecin derivative to a topoisomerase inhibitor compared to butyrylcholinesterase.
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申请公布号 |
US2008213281(A1) |
申请公布日期 |
2008.09.04 |
申请号 |
US20030535441 |
申请日期 |
2003.12.04 |
申请人 |
APPLIED MOLECULAR EVOLUTION, INC. C/O ELI LILLY AND COMPANY PATENT DIVISION |
发明人 |
WATKINS JEFFREY D.;PANCOCK JAMES D. |
分类号 |
A61K39/395;A61K38/00;A61K38/43;A61P35/00;C07D471/04;C07H19/00;C12N9/00;C12N9/18 |
主分类号 |
A61K39/395 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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