AGENT FOR ENHANCING THE RESISTANCE OF LIPOSOME AGAINST BIOLOGICAL COMPONENT, AND LIPOSOME MODIFIED WITH THE AGENT

摘要

The object is to enhance the resistance of a liposome having a positive charge (particularly having a polyarginine peptide) on its surface against a biological component having a negative charge (e.g., a protein contained in the blood), and to provide a liposome which can still exhibit a high inclusion material delivery ability even when the liposome is added to the blood. Specifically disclosed is an agent for enhancing the resistance of a liposome against a biological component. The agent comprises (a) a peptide having the amino acid sequence depicted in SEQ ID NO:1 or 2 and/or (b) a peptide which comprises an amino acid sequence having the deletion or addition of one or several amino acid residues in the aforementioned amino acid sequence and which has an activity of promoting the lipid membrane fusion under acidic conditions. The agent can be used in a liposome to thereby increase the resistance of the liposome against a biological component having a negative charge such a protein contained in the blood and enables the liposome to still exhibit a high inclusion material delivery ability even when the liposome is added to the blood.