ALPHA-1-ANTITRYPSIN VARIANTS AND USES THEREOF

摘要

The subject invention is directed to novel polynucleotides and polypeptides comprising SEQ ID NOs: 1 and 2. Also provided are fragments these polypeptides. The polynucleotides and polypeptides disclosed herein have been isolated from the liver cells (hepatocytes) of end stage liver failure patients and appear to be associated with a poor prognosis for these patients as relates to liver function. The subject application provides therapeutic methods and reagents for treating livers in which the polynucleotide and polypeptide of SEQ ID NO: 1 and 2 arc identified as well as diagnostic methods and reagents for identifying individuals at risk of liver failure. Finally, the subject invention also provides a system of the classification, revision or reordering of a classification system of liver transplant patients.