CELL CAPABLE OF EXPRESSING LACRITIN AT HIGH LEVEL

摘要

Disclosed is a means for producing lacritin stably in a large quantity. Specifically disclosed are: a vector comprising a polynucleotide encoding lacritin, wherein the nucleotide is operably linked to cytomegalovirus immediately early enhancer/promoter and SV40 late poly-A signal; a lacritin-expressing cell produced by introducing the vector into a cell; a process for producing recombinant lacritin, which comprises the steps of culturing the lacritin-expressing cell in a culture medium and isolating lacritin from a culture supernatant; and a therapeutic agent for an ophthalmic disease, which comprises the lacritin-expressing cell.