Paclitaxel enhancer compounds

摘要

Disclosed is a compound represented by the Structural Formula (I): Y is a covalent bond, a phenylene group or a substituted or unsubstituted straight chained hydrocarbyl group. In addition, Y, taken together with both >C=Z groups to which it is bonded, is a substituted or unsubstituted aromatic group. Preferably, Y is a covalent bond or -C(R₇R₈)-. R₁ and R₂ are independently an aryl group or a substituted aryl group, R₃ and R₄ are independently -H, an aliphatic group, a substituted aliphatic group, an aryl group or a substituted aryl group. R₅-R₆ are independently -H, an aliphatic group, a substituted aliphatic group, an aryl group or a substituted aryl group. R₇ and R₈ are each independently -H, an aliphatic or substituted aliphatic group, or R₇ is -H and R₈ is a substituted or unsubstituted aryl group, or, R₇ and R₈, taken together, are a C2-C6 substituted or unsubstituted alkylene group. Z is -O or -S. Also disclosed are pharmaceutical compositions comprising the compound of the present invention and a pharmaceutically acceptable carrier or diluent. Also disclosed is a method of treating a subject with cancer by administering to the subject a compound of Structural Formula (I) in combination with Paclitaxel or an analog of Paclitaxel.