| 摘要 |
<p>An implantable medical device capable of delivering therapeutic substances includes a roughened surface formed by ion beam etching. Ionized gas particles are shot at the medical device at high velocity to ablate portions of the surface of the medical device. The medical device, or a portion thereof, can be coated with a coating containing a therapeutic substance or substances, a polymer, or a combination of therapeutic substances and polymer. The coating can be made of one or more layers and the various layers can include different therapeutic substances, polymers, or combinations of therapeutic substances and polymers. The roughened surface has a greater surface area than a smooth surface, providing a better mechanical hold for the coating, thereby improving coating retention or therapeutic substance elution.</p> |
