IMPROVEMENTS IN AND RELATING TO MEDICINAL COMPOSITIONS

摘要

A composition, in parenteral unit dosage form or in a unit dosage form su itable for delivery via the dermis or mucosa, comprises buprenorphine and an amount of naloxone such that the ratio by weight of buprenorphine to naloxo ne delivered to or reaching the plasma of a patient is in the range of from 7.5:1 to 12.4:1. The analgesic action of the buprenorphine is potentiated by the low dose of naloxone, which also serves to reduce the likelihood of abu se of the composition by drug addicts. Also provided are a method of treatme nt of pain and the use of naloxone and buprenorphine for the manufacture of a medicament.