发明名称 |
DNA coding for polypeptide participating in biosynthesis of pladienolide |
摘要 |
The present invention provides polypeptides that participate in the biosynthesis of the pladienolide macrolide compounds, DNA that encodes these polypeptides and variants of this DNA, transformants that maintain all or a portion of this DNA or variant thereof, and a method of producing the pladienolide macrolide compounds using these transformants. More particularly, it provides an isolated pure DNA that contains at least one region encoding a polypeptide that participates in pladienolide biosynthesis; polypeptide encoded by this DNA; a self-replicating or integrated-replicating recombinant plasmid carrying this DNA; a transformant maintaining this DNA; and a method of producing a pladienolide, characterized by culturing this transformant on culture medium and collecting pladienolide from this culture medium. |
申请公布号 |
AU2005265443(B2) |
申请公布日期 |
2008.09.04 |
申请号 |
AU20050265443 |
申请日期 |
2005.07.19 |
申请人 |
EISAI R & D MANAGEMENT CO., LTD;MERCIAN CORPORATION |
发明人 |
KAZUHIRO MACHIDA;SUSUMU TAKEDA;TOSHIO TSUCHIDA;AKIRA ARISAWA;MASASHI YOSHIDA |
分类号 |
C12N15/52;C07K14/36;C12N1/15;C12N1/19;C12N1/21;C12N5/10;C12N9/00;C12N9/02;C12P17/16 |
主分类号 |
C12N15/52 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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