发明名称 |
Macrocycles useful in the treatment of Alzheimer's disease |
摘要 |
The present invention are macrocycles of the formula (IX): for treating Alzheimer's disease and other similar diseases. These compounds include inhibitors of the beta-secretase enzyme that are useful in the treatment of Alzheimer's disease and other diseases characterized by deposition of A beta peptide in a mammal. The compounds of the invention are useful in pharmaceutical compositions and methods of treatment to reduce A beta peptide formation.
|
申请公布号 |
US6969709(B2) |
申请公布日期 |
2005.11.29 |
申请号 |
US20020171182 |
申请日期 |
2002.06.12 |
申请人 |
PHARMACIA & UPJOHN COMPANY |
发明人 |
PULLEY SHON R.;BECK JAMES P.;TENBRINK RUTH E. |
分类号 |
A61K31/395;A61K31/4427;A61P25/28;C07D273/02;C07D413/12;(IPC1-7):C07D413/12;A61K31/442 |
主分类号 |
A61K31/395 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|