5,6-Dihydropyrin-2-one compounds useful as inhibitors of thrombin

摘要

There is provided a compound of formula (I) wherein R¹, R^2a, R^2b, R^3a, R^3b, R⁴, R⁵, R⁶, A, G and L have meanings given in the description, which compounds are useful as, or are useful as prodrugs of, competitive inhibitors of trypsin-like proteases, such as trombin, and thus, in particular, in the treatment of conditions where inhibition of thrombin is beneficial (e.g. conditions, such as thrombo-embolisms, where inhibition of trombin is required or desired, and/or conditions whereas anticoagulant therapy is indicated).