发明名称 |
USES FOR CAMKII AND HDACS IN THE TREATMENT OF HEART CONDITIONS |
摘要 |
<p>The present invention provides for methods of treating and cardiac hypertrophy, heart failure, dilated cardiomyopathy or hypertension comprising the use of CaMKII-HDAC binding domains. The present invention discloses not only the fact that CaMKII binds to HDAC4 at a specific site, but that HDAC4 may dimerize with other HDACs. Both events can lead to export of HDACs from the nucleus to the cytoplasm, an event associated with the development of heart disease. Thus the methods of treatment and the screening methods of the present invention are novel attempts to prevent, treat or identify therapies for cardiac hypertrophy, heart failure, dilated cardiomyopathy or hypertension.</p> |
申请公布号 |
EP1962888(A2) |
申请公布日期 |
2008.09.03 |
申请号 |
EP20060848422 |
申请日期 |
2006.11.17 |
申请人 |
MYOGEN, INC. |
发明人 |
BACKS, JOHANNES;HARRISON, BROOKE;HUYNH, KHAI;KOCH, KEITH;MCKINSEY, TIM;OLSON, ERIC;PAGRATIS, NIKOS |
分类号 |
A61K38/46;A61P9/04;G01N33/50 |
主分类号 |
A61K38/46 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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