发明名称 |
OXIDIZED PROTEINS, THEIR BIOLOGICAL ACTIVITY, AND THERAPEUTIC AND DIAGNOSTIC MEASURES, WHICH ARE DERIVED FROM THE ACTIVE MECHANISM, FROM THE USE OF THESE PROTEINS OR FROM THE INHIBITION THEREOF |
摘要 |
<p>Medicaments (A and B) for use in humans or animals are new. (A) contains an agent (I) which inhibits the binding of oxidized proteins to CD36 or the functions of CD36 induced by oxidized proteins. (B) contains at least one oxidized protein (II) or oxidized peptide (or a structural analog or mimetic) An independent claim is included for the preparation of oxidized proteins/peptides, involving reaction with hypochlorous acid or peroxynitrites. - ACTIVITY : Anticoagulant; Thrombolytic; Antiinflammatory; Immunosuppressive; Antiarteriosclerotic; Hypotensive; Nephrotropic; Vasotropic; Cardiant; Cerebroprotective; Antidiabetic; Vulnerary; Antibacterial; Anti-HIV; Cytostatic; Antirheumatic; Antiarthritic; Antiulcer; Dermatological. - MECHANISM OF ACTION : CD36 antagonist; CD36 agonist.</p> |
申请公布号 |
EP1328289(B1) |
申请公布日期 |
2008.09.03 |
申请号 |
EP20010983562 |
申请日期 |
2001.10.19 |
申请人 |
HAMBURGER STIFTUNG ZUR FOERDERUNG VON WISSENSCHAFT UND KULTUR |
发明人 |
KEHREL, BEATE;BRODDE, MARTIN |
分类号 |
A61K38/39;A61K45/00;A61K38/00;A61K38/17;A61K39/395;A61P7/00;A61P7/02;A61P9/00;A61P9/08;A61P9/10;A61P9/12;A61P17/02;A61P29/00;A61P37/06;A61P43/00;C07K1/107;C07K14/705;C07K16/28;G01N33/50 |
主分类号 |
A61K38/39 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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