发明名称 |
PROTEIN TYROSINE PHOSPHATASES OF HEMATOPOIETIC CELLS |
摘要 |
This invention concerns new non-receptor protein tyrosine phosphatases of the hematopoietic stem cells (PTP HSC). The invention specifically concerns native murine and human PTP HSCs, their analogs in other mammals, and their functional derivatives. The invention further relates to nucleic acid encoding these proteins, vectors containing and capable of expressing such nucleic acid, and recombinant host cells transformed with such nucleic acid. Assays for identifying agonists and antagonists of the native PTP HSCs, methods for expansion of undifferentiated stem cells, and methods for the induction of stem cell differentiation are also within the scope of the invention.
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申请公布号 |
CA2246430(C) |
申请公布日期 |
2008.09.02 |
申请号 |
CA19972246430 |
申请日期 |
1997.03.17 |
申请人 |
GENENTECH, INC. |
发明人 |
LASKY, LAURENCE A.;CHENG, JILL |
分类号 |
C12N15/02;C12N15/55;A61K31/00;A61K38/00;A61K38/18;A61K38/22;A61K38/43;A61K39/395;A61K45/00;A61P35/00;A61P35/02;A61P43/00;C07K16/40;C12N5/06;C12N5/08;C12N5/10;C12N5/18;C12N9/16;C12N9/88;C12N15/09;C12P21/02;C12P21/08;C12Q1/02;C12Q1/42;C12Q1/68;C12R1/91;G01N33/50 |
主分类号 |
C12N15/02 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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