| 发明名称 |
PRODUCTION OF F(AB')2 FRAGMENTS IN MAMMALIAN CELLS |
| 摘要 |
<p>The present invention provides immortalized eukaryotic cells and methods useful for the production of immunologically active bivalent antibody fragments, such as F(ab')2 fragments. The methods and cells of the invention result in a desirable ratio of bivalent to monovalent antibody fragments.</p> |
| 申请公布号 |
SI1456238(T1) |
申请公布日期 |
2008.08.31 |
| 申请号 |
SI20020030701T |
申请日期 |
2002.12.17 |
| 申请人 |
CRUCELL HOLLAND B.V. |
发明人 |
BOUT ABRAHAM;JONES DAVID HALFORD ASHTON |
| 分类号 |
C07K16/18;A61K39/395;C07K16/00;C12N5/06;C12N5/08;C12N5/10;C12N15/85;C12N15/86 |
主分类号 |
C07K16/18 |
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