CONDENSED PYRIMIDINE DERIVATIVES AS INHIBITORS OF FOIC ACID-DEPENDENT ENZYMES

摘要

The invention relates to compounds of the formula I, useful as inhibitors of folic acid-dependent enzymes, or pharmaceutically acceptable salts thereof:
wherein:
Z= O or S;
B=-NR 2 -, -CH 2 NR 2 -, -CH 2 CH 2 NR 2 -, -CH 2 CHR 7 - or -CH 2 O-,
wherein R 2 is H or a C 1-3 alkyl, alkenyl or alkynyl group, and
R 7 is H or a C 1-3 alkyl or alkoxy group;
A=
and n, R 3 , R 4 are defined as in the claims.