COMPUESTOS DERIVADOS DE PIRROLIDIN-AMIDA INHIBIDORES DE LA PROTEASA ACTIVADORA DE CANAL; COMPOSICION FARMACEUTICA QUE COMPRENDE A DICHOS COMPUESTOS; Y SU USO PARA TRATAR FIBROSIS QUISTICA, BRONQUITIS CRONICA, CANCER DE PULMON ENTRE OTRAS ENFERMEDADES

摘要

The invention provides compounds and pharmaceutical compositions thereof, which are useful for modulating chan-nel activating proteases, and methods for using such compounds to treat, ameliorate or prevent a condition associated with a channel activating protease, including but not limited to prostasin, PRSS22, TMPRSS11 (e.g., TMPRSS11B, TMPRSSI1E), TMPRSS2, TMPRSS3, TMPRSS4 (MTSP-2), matriptase (MTSP-1), CAP2, CAP3, trypsin, cathepsin A, or neutrophil elastase.