NEW MANDELIC ACID DERIVATIVES AND THEIR USE AS THROMBIN INHIBITORS

摘要

THERE IS PROVIDED A COMPOUND OF FORMULA 1 WHEREIN R A ,R1,R2,Y AND R3 HAVE MEANINGS GIVEN IN THE DESCRIPTION AND PHARMACEUTICALLY-ACCEPTABLE DERIVATIVES (INCLUDING PRODRUGS)THEREOF, WHICH COMPOUNDS AND DERIVATIVES ARE USEFUL AS, OR ARE USEFUL AS PRODRUGS OF, COMPETITVE INHIBITORS OF TRYPSIN-LIKE PROTEASES, SUCH AS THROMBIN, AND THUS, IN PARTICULAR, IN THE TREATMENT OF CONDITIONS WHERE INHIBITION OF THROMBIN IS REQUIRED (E.G THROMBOSIS ) OR AS ANTICOAGULANTS.