发明名称 |
Diphenylethylene compounds and uses thereof |
摘要 |
Disclosed is a diphenylethylene compound of formula (I) or a pharmaceutically acceptable salt, solvate or hydrate thereof, wherein the substituents are described within the specification. Also disclosed is the use of the above compound for the preparation of a composition for inhibiting angiogenesis, for inhibiting or reducing tubulin polymerization or tubulin stability in a cell, for inhibiting PDE4 activity in a cell, for treating or ameliorating an inflammatory disorder, for inhibiting or ameliorating cancer and for treating or ameliorating a central nervous system disorder.
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申请公布号 |
NZ542407(A) |
申请公布日期 |
2008.08.29 |
申请号 |
NZ20040542407 |
申请日期 |
2004.03.05 |
申请人 |
CELGENE CORPORATION |
发明人 |
MULLER, GEORGE W;PAYVANDI, FARIBOURZ;ZHANG, LING H;ROBARGE, MICHAEL J;CHEN, ROGER;MAN, HON-WAH |
分类号 |
A61K;A61K31/165;A61K31/18;A61K31/24;A61K31/275;A61K31/277;A61K31/40;A61K31/44;A61K31/66;C07C43/215;C07C45/68;C07C49/255;C07C205/37;C07C233/33;C07C255/35;C07C255/37;C07C255/43;C07C255/44;C07C275/38;C07C311/60;C07D317/60;C07D319/18;C07D319/20;C07F9/12;C07F9/28;(IPC1-7):C07C233/33 |
主分类号 |
A61K |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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