| 摘要 |
FIELD: chemistry. ^ SUBSTANCE: invention pertains to new sulphamines with general formula (I) , where R1 represents (low) alkyl-O-(CH2)n-; R2 represents Ra-Y-(CH2)m-; R3 represents phenyl, which can be replaced by such substitutes as halogen, (low) alkyl or (low)alkoxy; R4 represents hydrogen; R6 represents hydrogen; X represents oxygen or a bond; Y represents a bond of -O-; n is equal to 2; m is equal to 2; Ra represents heteroaryl, in form of a 6-member aromatic ring, containing two nitrogen atoms, which can be substituted with such substitutes as halogen, thio(low)alkyl or (low)alkoxy; and their pharmaceutical salts. The invention also pertains to related objects, including the method of obtaining the following compounds formula II , formula III , formula IV , formula V , where radicals assume values indicated above or in the description. ^ EFFECT: invented compounds can be used as active ingredients for obtaining pharmaceutical compositions, which have inhibiting effect to endothelial receptors. ^ 13 cl, 4 ex, 3 dwg, 2 tbl |
