MODIFIED ENZYME AND TREATMENT METHOD

摘要

There is disclosed an isolated, modified recombinant .beta.-glucuronidase wherein the modification is having its carbohydrate moeties chemically modi fied so as to reduce its activity with respect to mannose and mannose 6-phos phate cellular delivery system while retaining enzymatic activity Also discl osed are methods for the treatment of lysosomal storage disease in mammals w herein the mammal is administered a therapeutically effective amount of isol ated, modified recombinant .beta.-glucuronidase whereby said storage disease d is relieved in the brain and visceral organs of the mammal. Also disclosed are other lysosomal enzymes within the scope of the invention.