Phenylpiperazines with a combination of affinity for dopamine - D2 receptors and serotonin reuptake sites
摘要
The invention relates to a group of novel phenylpiperazine derivatives with a dual mode of action: serotonin reuptake inhibition and affinity for dopamine -D2 receptors and to methods for the preparation of these compounds. The invention also relates to the use of a compound disclosed herein for the manufacture of a medicament giving a beneficial effect. The compounds have the general formula ( 1 ) wherein the symbols have the meanings given in the specification.
申请公布号
ZA200704151(B)
申请公布日期
2008.08.27
申请号
ZA20070004151
申请日期
2007.05.22
申请人
SOLVAY PHARMACEUTICALS B.V.
发明人
VAN HES, ROELOF;KRUSE, CORNELIS G.;SMID, PIETER;TULP, MARTINUS TH.M.