| 摘要 |
FIELD: chemistry. ^ SUBSTANCE: invention relates to the method of production of analogues of natural alkaloids of harman series (eleagnine) having potential biological activity, namely, to the method of 1-substituted -4phenyl-2,3,4,9-terahydro-1H-beta-carboline of general formula where one of R1 and R2 denotes hydrogen atom, and the other represents alkyl with 1 or 2 hydrogen atoms or aryl, hetaryl, or R1 and R2 together with carbon atom to which they are banded derive optionally substituted indol-3-on. The method is cyclisation of aldehydes by substituted tryptamine with acids, at the same time beta-phenyltryptamine is used as substituted tryptamine, aliphatic or aromatic aldehydes or optionally substituted isatins are used as aldehydes, mineral salts or Lewis catalysts are used as acids. ^ EFFECT: production of analogues of natural alkaloids of harman series (eleagnine) having potential biological activity. ^ 1 cl, 4 tbl, 14 ex |
